灌个水---水楼NUMBER.1

凤鸾

闲来无聊，其实也不是没事做，只是不想做事，

建个水楼发泄，发泄。

最近打算---把项目QC完，然后买个篮球，然后每天下班去打小会篮球，有没有朋友打算一起研究，看一本SAS书，然后每个人对所研究的这个章节做个PPT或者视频。。。一起学习有动力！

275932488

我报个名吧，教材你比较有经验，你推荐，一起学习有动力。

凤鸾

Analysis of Clinical Trials Using SAS --A Practical Guide by Alex Dmitrienko.一共5章节。
contents:
1 Analysis of Stratified Data 1
1.1 Introduction 1
1.2 Continuous Endpoints 3
1.3 Categorical Endpoints 19
1.4 Time-to-Event Endpoints 40
1.5 Tests for Qualitative Interactions 56
2 Multiple Comparisons and Multiple Endpoints 67
2.1 Introduction 67
2.2 Single-Step Tests 70
2.3 Closed Testing Methods 74
2.4 Fixed-Sequence Testing Methods 84
2.5 Resampling-Based Testing Methods 89
2.6 Testing Procedures for Multiple Endpoints 94
2.7 Gatekeeping Strategies 104
3 Analysis of Safety and Diagnostic Data 129
3.1 Introduction 129
3.2 Reference Intervals for Safety and Diagnostic Measures 130
3.3 Analysis of Shift Tables 157
4 Interim Data Monitoring 177
4.1 Introduction 177
4.2 Repeated Significance Tests 181
4.3 Stochastic Curtailment Tests 235
5 Analysis of Incomplete Data 269
5.1 Introduction 269
5.2 Case Studies 271
5.3 Data Setting and Modeling Framework 273
5.4 Analysis of Complete Growth Data 276
5.5 Simple Methods and MCAR 287
5.6 Available Case Methods 300
5.7 Likelihood-Based Ignorable Analyses 301
iv Analysis of Clinical Trials Using SAS: A Practical Guide
5.8 Multiple Imputation 308
5.9 The EM Algorithm 326
5.10 Categorical Data 332
5.11 MNAR and Sensitivity Analysis 353
5.12 Summary 354
Appendix 355
References 391
Index 405
另一本：Common Statistical Methods for
Clinical Research: with SAS® Examples by Glenn A. WalkerChapter 1 - Introduction & Basics
1.1 Statistics—the Field ....................................................................................................................1
1.2 Probability Distributions ...........................................................................................................4
1.3 Study Design Features ...............................................................................................................9
1.4 Descriptive Statistics ................................................................................................................13
1.5 Inferential Statistics .................................................................................................................16
1.6 Summary ..................................................................................................................................21
Chapter 2 – Topics in Hypothesis Testing
2.1 Significance Levels ....................................................................................................................23
2.2 Power ........................................................................................................................................25
2.3 One-Tailed and Two-Tailed Tests ............................................................................................26
2.4 p-Values ....................................................................................................................................27
2.5 Sample Size Determination .....................................................................................................27
2.6 Multiple Testing ........................................................................................................................30
2.7 Summary ..................................................................................................................................38
Chapter 3 – The Data Set TRIAL
3.1 Introduction..............................................................................................................................39
3.2 Data Collection .........................................................................................................................39
3.3 Creating the Data Set TRIAL.................................................................................................. 42
3.4 Statistical Summarization .......................................................................................................45
3.5 Summary...................................................................................................................................54
Chapter 4 – The One-Sample t-Test
4.1 Introduction..............................................................................................................................55
4.2 Synopsis ....................................................................................................................................55
4.3 Examples ..................................................................................................................................56
4.4 Details & Notes .........................................................................................................................64
Chapter 5 – The Two-Sample t-Test
5.1 Introduction..............................................................................................................................67
5.2 Synopsis ....................................................................................................................................67
5.3 Examples ..................................................................................................................................68
5.4 Details & Notes .........................................................................................................................73
iv Table of Contents
Chapter 6 – One-Way ANOVA
6.1 Introduction..............................................................................................................................77
6.2 Synopsis ....................................................................................................................................77
6.3 Examples ..................................................................................................................................80
6.4 Details & Notes .........................................................................................................................86
Chapter 7 – Two-Way ANOVA
7.1 Introduction..............................................................................................................................91
7.2 Synopsis ....................................................................................................................................91
7.3 Examples ..................................................................................................................................94
7.4 Details & Notes .......................................................................................................................107
Chapter 8 – Repeated Measures Analysis
8.1 Introduction............................................................................................................................111
8.2 Synopsis ..................................................................................................................................111
8.3 Examples ................................................................................................................................115
8.4 Details & Notes .......................................................................................................................148
Chapter 9 – The Crossover Design
9.1 Introduction............................................................................................................................157
9.2 Synopsis ..................................................................................................................................158
9.3 Examples ................................................................................................................................160
9.4 Details & Notes .......................................................................................................................171
Chapter 10 – Linear Regression
10.1 Introduction............................................................................................................................175
10.2 Synopsis ..................................................................................................................................175
10.3 Examples ................................................................................................................................178
10.4 Details & Notes .......................................................................................................................193
Chapter 11 – Analysis of Covariance
11.1 Introduction............................................................................................................................199
11.2 Synopsis ..................................................................................................................................200
11.3 Examples ................................................................................................................................203
11.4 Details & Notes .......................................................................................................................221
Chapter 12 – The Wilcoxon Signed-Rank Test
12.1 Introduction............................................................................................................................227
12.2 Synopsis ..................................................................................................................................227
12.3 Examples ................................................................................................................................228
12.4 Details & Notes .......................................................................................................................234
Chapter 13 – The Wilcoxon Rank-Sum Test
13.1 Introduction............................................................................................................................237
13.2 Synopsis ..................................................................................................................................237
13.3 Examples ................................................................................................................................239
13.4 Details & Notes .......................................................................................................................244
Table of Contents v
Chapter 14 – The Kruskal-Wallis Test
14.1 Introduction............................................................................................................................247
14.2 Synopsis ..................................................................................................................................247
14.3 Examples ................................................................................................................................249
14.4 Details & Notes .......................................................................................................................253
Chapter 15 – The Binomial Test
15.1 Introduction............................................................................................................................257
15.2 Synopsis ..................................................................................................................................257
15.3 Examples ................................................................................................................................259
14.4 Details & Notes .......................................................................................................................261
Chapter 16 – The Chi-Square Test
16.1 Introduction............................................................................................................................265
16.2 Synopsis ..................................................................................................................................265
16.3 Examples ................................................................................................................................267
16.4 Details & Notes........................................................................................................................279
Chapter 17 – Fisher’s Exact Test
17.1 Introduction............................................................................................................................285
17.2 Synopsis ..................................................................................................................................285
17.3 Examples ................................................................................................................................286
17.4 Details & Notes........................................................................................................................289
Chapter 18 – McNemar’s Test
18.1 Introduction............................................................................................................................293
18.2 Synopsis ..................................................................................................................................293
18.3 Examples ................................................................................................................................294
18.4 Details & Notes........................................................................................................................301
Chapter 19 – The Cochran-Mantel-Haenszel Test
19.1 Introduction............................................................................................................................305
19.2 Synopsis ..................................................................................................................................305
19.3 Examples ................................................................................................................................307
19.4 Details & Notes........................................................................................................................313
Chapter 20 – Logistic Regression
20.1 Introduction............................................................................................................................317
20.2 Synopsis ..................................................................................................................................318
20.3 Examples ................................................................................................................................322
20.4 Details & Notes........................................................................................................................340
Chapter 21 – The Log-Rank Test
21.1 Introduction............................................................................................................................349
21.2 Synopsis ..................................................................................................................................350
21.3 Examples.................................................................................................................................351
21.4 Details & Notes........................................................................................................................359
vi Table of Contents
Chapter 22 – The Cox Proportional Hazards Model
22.1 Introduction............................................................................................................................365
22.2 Synopsis ..................................................................................................................................366
22.3 Examples.................................................................................................................................367
22.4 Details & Notes........................................................................................................................376
Chapter 23 – Exercises
23.1 Introduction............................................................................................................................381
23.2 Exercises .................................................................................................................................381
23.3 Appropriateness of the Methods ...........................................................................................383
23.4 Summary.................................................................................................................................387
Appendix A – Probability Tables
A.1 Probabilities of the Standard Normal Distribution.............................................................390
A.2 Critical Values of the Student t-Distribution.......................................................................391
A.3 Critical Values of the Chi-Square Distribution...................................................................392
Appendix B – Common Distributions Used in Statistical Inference
B.1 Notation...................................................................................................................................393
B.2 Properties................................................................................................................................394
B.3 Results .....................................................................................................................................395
B.4 Distributional Shapes..............................................................................................................397
Appendix C – Basic ANOVA Concepts
C.1 Within- vs. Between-Group Variation..................................................................................399
C.2 Noise Reduction by Blocking .................................................................................................401
C.3 Least Squares Mean (LS-mean) ............................................................................................405
Appendix D – SS Types I, II, III, and IV Methods for an Unbalanced
Two-Way Layout
D.1 SS Types Computed by SAS..................................................................................................409
D.2 How to Determine the Hypotheses Tested ...........................................................................411
D.3 Empty Cells.............................................................................................................................416
D.4 More Than Two Treatment Groups.....................................................................................417
D.5 Summary.................................................................................................................................419
Appendix E – Multiple Comparison Methods
E.1 Multiple Comparisons of Means ...........................................................................................421
E.2 Multiple Comparisons of Binomial Proportions..................................................................432
E.3 Summary.................................................................................................................................436
Appendix F – Data Transformations
F.1 Introduction............................................................................................................................437
F.2 The Log Transformation........................................................................................................438
Appendix G – SAS Code for Exercises in Chapter 23....................................................441
References .............................................................................................................................................447
Index ..................................................................................................................................................453
一共22章节。


这2本书都是医药中SAS运行到的一些统计知识。二选一，嘿嘿嘿

275932488

凤鸾 发表于 2011-7-1 11:09
Analysis of Clinical Trials Using SAS --A Practical Guide by Alex Dmitrienko.一共5章节。
contents:
...

第一本看过去比较少。其他人看看。

蝶谷医仙

本人能力有限，热情是无限的。

凤鸾

蝶谷医仙 发表于 2011-7-3 19:14
本人能力有限，热情是无限的。

有热情就已经非常好了。

凤鸾

那我也觉得第二本比较好。内容比较丰富而且差不多都学过。看起来也比较容易。
然后再结合书里面的例子，更好地掌握用SAS来做统计分析。只不过人太少啊，20多章，可以多拉一些人来穴学，每个人负责2,3章，如果10个人，那么一周的时间就可以看完1本书。如果是5个人，每个人负责4章，2周就可以看完一本书，这只是偶的一个想法，哦呵呵呵~ ~～

晚风

路过看看，挺热闹的。

蝶谷医仙

凤鸾 发表于 2011-7-4 21:28
有热情就已经非常好了。

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